| REVIEW ARTICLE |
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| Year : 2020 | Volume
: 32
| Issue : 4 | Page : 153-156 |
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Prostate cancer therapies and fertility: What do we really know?
Panagiotis Mourmouris1, Lazaros Tzelves1, Titos Deverakis1, Lazaros Lazarou1, Kimon Tsirkas1, Anastasia Fotsali2, Christiana Roidi2, Ioannis Varkarakis1
1 2nd Department of Urology, Sismanogleio General Hospital, National and Kapodistrian University of Athens, Athens, Greece
2 2nd nd Deparment of Urology, Athens Medical School, National and Kapodistrian University of Athens, Sismanogleio General Hospital, Athens, Greece
Correspondence Address:
Panagiotis Mourmouris
2nd Department of Urology, Sismanogleio General Hospital, National and Kapodistrian University of Athens, 1st Sismanogleiou Str, Marousi 15125, Athens
Greece
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/HUAJ.HUAJ_9_21
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We reviewed the literature for articles in English in the Medline database from 1970 until today. The keywords used were “prostate cancer,” “fertility,” “radical prostatectomy,” “external beam radiotherapy,” “androgen deprivation therapy,” and “chemotherapy.” Only the studies with full paper were included in our review. The knowledge for this important issue is minimal and more minimal tends to be the consent of the patients. Prostate cancer does not seem to directly influence fertility, but all its therapies directly or indirectly seem to do so. In many of them, the impact may be reversible, but the mechanisms of this impact are still under consideration. Prostate cancer treatments, predominantly radiation, can cause long-term azoospermia; however, the data in the literature are sparse, mainly derived from small series, and based on these, no safe conclusions can be drawn.
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